Diethylenetriaminepentaacetic acid (DTPA)

Technical specifications 6-09-07-1673-88

   DTPA is an edetate and a chelating agent used in preparing radiopharmaceuticals. DTPA has a strong affinity for iron and other heavy metals, thereby is used in the treatment of poisoning from heavy and radioactive metals. DTPA may chelate metallic moieties of unbound, extracellular radio-immunotherapeutics, thereby aggregating radioimmunotherapeutics locally to higher concentrations, and  improving tumor cell radiocytotoxicity, while sparing normal tissues from the radiocytotoxic effects. It is also used as a color stabilizer for synthetic fiber and as a titrant.